DOI:
https://doi.org/10.38017/1657463X.593Palabras clave:
hiperparatiroidismo, resorción ósea, CTX, osteítis fibrosa, biomarcadoresResumen
La importancia del calcio en muchos procesos metabólicos es conocida, y su importante relación con la salud y las bajas tasas de supervivencia han sido reportadas. En Colombia, el hiperparatiroidismo secundario nutricional por deficiencias de calcio, está reportado y ha sido reconocido desde hace décadas como patología con signos clínicos que se hacen evidentes tardíamente y puede comenzar con signos leves como claudicaciones intermitentes, pero solo pacientes con cambios severos son evaluados por desmineralización, principalmente en huesos de la cabeza. Esto genera un gran impacto por pérdida de animales por problemas musculoesqueléticos. Adicional a esto, múltiples factores nutricionales y de manejo en la producción equina en el país, pueden afectar la absorción y el metabolismo de calcio, exacerbando la incidencia de la enfermedad. Y aunque se realizan pruebas diagnósticas, solo confirman el cuadro avanzado y no se han estudiado pruebas para un diagnóstico temprano de resorción, antes que las lesiones avancen. El objetivo es entender la enfermedad y evaluar la posibilidad diagnóstica del Telopéptido carboxilo terminal del colágeno I (CTX I) en una etapa temprana de la enfermedad disminuyendo su impacto atlético y económico. Se realizó revisión de fuentes impresas y electrónicas, consultando bases de datos y revistas depositadas en Universidades, sin restricción de fecha, con descriptores en todos los idiomas relacionados a la enfermedad y diagnóstico. Y se evaluaron las opciones del uso de CTX en el diagnóstico de problemas de resorción ósea.
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